This week’s sciku takes me back 20 years to my job as a group home counselor. We were trying to help adults with schizophrenia manage their lives and illnesses more independently, but the medication, which was so necessary, also made it difficult.
Antipsychotic medication needs cross the blood-brain barrier to work, but when you swallow a pill, only a small fraction makes it through. As a result, the effective dose is much larger than it would be otherwise, leading to very unpleasant side effects—from weight gain and fatigue to diabetes and eventually organ toxicity. Many patients had to take multiple drugs hoping to counteract the side-effects. And once they found a combination that worked, it would only last a while before they had to start over with an entirely new regimen due to the accumulating toxicity. It was rough—but still better than the hell of psychosis.
So I was thrilled to learn that researchers at McMaster University have developed a nasal spray using extremely fine particles of corn starch to deliver antipsychotic medication more directly into the brain, sneaking it through a hidden door along the olfactory nerve. The corn starch breaks down into simple sugar, but gradually, allowing it to be time-released with a 75% lower effective dose. Instead of taking medication multiple times each day, patients will only have to use a nasal spray once every three days, with far fewer side effects. The difference this will make for people’s quality of life is huge.
And that’s what I love about reading science news. Unlike what we call “The News,” where negativity bias is exploited for clicks, science incentivizes the good—it’s mostly mysteries solved, problems fixed, new questions to ponder. And there’s something new every week. This time with a bonus one-liner.
the men line up
for their meds
more drizzle than mist refilling the pill box